Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo, Tokyo 113-8657, Japan.
J Plant Res. 2011 Jul;124(4):549-57. doi: 10.1007/s10265-011-0415-0. Epub 2011 Apr 2.
Chemical biology is a discipline that utilizes chemicals to elucidate biological mechanisms and physiological functions. Various abscisic acid (ABA) derivatives have revealed the structural requirement for the perception by ABA receptors while biotin or caged derivatives of ABA have disclosed the localization of several ABA-binding proteins. Recently, selective ABA agonist has been used to identify ABA receptors. Furthermore, ABA biosynthesis and catabolic inhibitors have contributed to the identification of new ABA functions in plant growth and development. The physiological function of ABA in non-plant organisms has gradually been revealed. In this review, we discuss the development of small bioactive chemicals and their significance in ABA research.
化学生物学是利用化学物质来阐明生物机制和生理功能的一门学科。各种脱落酸（ABA）衍生物揭示了 ABA 受体感知的结构要求，而生物素或 ABA 的笼状衍生物则揭示了几种 ABA 结合蛋白的定位。最近，选择性 ABA 激动剂已被用于鉴定 ABA 受体。此外，ABA 生物合成和分解代谢抑制剂有助于确定 ABA 在植物生长发育中的新功能。ABA 在非植物生物中的生理功能逐渐被揭示。在这篇综述中，我们讨论了小生物活性化学物质的发展及其在 ABA 研究中的意义。
