Herkommer K, Schmidt C, Gschwend J E
Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675 München, Deutschland.
Urologe A. 2011 Jul;50(7):813-20. doi: 10.1007/s00120-011-2552-4.
The German national research project"familial prostate cancer" has been recruiting prostate cancer patients nationwide since 1999. In 2009, a comprehensive data analysis of the 25,065 families recruited was performed. Of these, 77.4% were identified as sporadic, 20.0% as familial and 2.6% as hereditary cases of prostate cancer. However, obtaining comprehensive, validated information about all relatives often fails.
The high average age of the patients, the lower life expectancy in further generations and the low number of first-degree male relatives hampers the classification of sporadic, familial and hereditary cases. Consequently we describe here that in our database the identification of 100 hereditary cases requires a recruitment of more than 5,000 patients with their families. For 100 sporadic patients with 2 first-degree male relatives without a case history 1,250 patients are needed.
德国国家研究项目“家族性前列腺癌”自1999年起在全国范围内招募前列腺癌患者。2009年，对招募的25065个家庭进行了全面的数据分析。其中，77.4%被确定为散发性，20.0%为家族性，2.6%为遗传性前列腺癌病例。然而，获取所有亲属的全面、经过验证的信息往往难以实现。
患者的平均年龄较高、后代预期寿命较低以及一级男性亲属数量较少，阻碍了散发性、家族性和遗传性病例的分类。因此，我们在此描述，在我们的数据库中，识别100例遗传性病例需要招募超过5000名患者及其家属。对于100例有2名无病史的一级男性亲属的散发性患者，需要1250名患者。
