通过高效液相色谱-圆二色光谱/紫外光谱法和量子化学计算确定大环双苄基的阻转异构体构型
Determination of atropisomeric configurations of macrocyclic bisbibenzyls by HPLC-CD/UV and quantum chemical calculations.
作者信息
Wang Li-Ning, Xie Chun-Feng, Zhu Xiao-Song, Fan Pei-Hong, Lou Hong-Xiang
机构信息
School of Pharmaceutical Sciences, Shandong University, Jinan, China.
出版信息
J Asian Nat Prod Res. 2011 Apr;13(4):312-8. doi: 10.1080/10286020.2011.555333.
Isoriccardin C (1) and riccardin D (2), isolated from the liverwort Reboulia hemisphaerica, were first characterized to be a mixture of two enantiomeric atropisomers by online chiral high-performance liquid chromatography-circular dichroism (HPLC-CD) analysis. Exemplarily for bisbibenzyls of the diarylether-biphenyl type, the absolute atropisomeric configurations of compunds 1 and 2 were determined by the analysis of their CD data coupled with quantum chemical CD calculations.
从半叶鳞苔中分离得到的异卡地辛C（1）和卡地辛D（2），通过在线手性高效液相色谱 - 圆二色光谱（HPLC - CD）分析，首次被鉴定为两种对映体阻转异构体的混合物。作为二芳基醚 - 联苯型双苄基化合物的示例，通过对化合物1和2的圆二色光谱数据进行分析并结合量子化学圆二色光谱计算，确定了它们的绝对阻转异构构型。
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