来自地钱日本全萼苔的芳香化合物。

Aromatic compounds from the liverwort Conocephalum japonicum.

作者信息

Liu Na, Guo Dong-Xiao, Wang Yan-Yan, Wang Li-Ning, Ji Mei, Lou Hong-Xiang

机构信息

Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.

出版信息

Nat Prod Commun. 2011 Jan;6(1):49-52.

PMID:21366044

Abstract

Two undescribed dimeric ArC2 derivatives, cis- and trans-1,2-bis(3,4-dimethoxyphenyl)cyclobutane (1 and 2), one new monoterpenes esters, 2alpha,5beta-dihydroxybornane-2-cis-cinnamate (3), along with eight known compounds, 2alpha,5beta-dihydroxybornane-2-trans-cinnamate (4), perrottetin E (5), isoriccardin C (6), marchantin A (7), marchantin E (8), marchantin C (9), and isomarchantin C (10) were isolated from the liverwort Conocephalum japonicum. All the structures were established by extensive spectroscopic analysis. The isolated compounds 3-10 were evaluated for their cytotoxicity against the human KB cell line with IC50 values ranging from 16.5 to 50.2 microM.

摘要

从地钱日本蛇苔中分离出两种未描述的二聚体ArC2衍生物，顺式和反式-1,2-双（3,4-二甲氧基苯基）环丁烷（1和2），一种新的单萜酯，2α,5β-二羟基冰片-2-顺式肉桂酸酯（3），以及八种已知化合物，2α,5β-二羟基冰片-2-反式肉桂酸酯（4），佩罗替汀E（5），异鼠李素C（6），桑黄菌素A（7），桑黄菌素E（8），桑黄菌素C（9）和异桑黄菌素C（10）。所有结构均通过广泛的光谱分析确定。对分离出的化合物3-10进行了针对人KB细胞系的细胞毒性评估，IC50值范围为16.5至50.2 microM。