Division of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Nutr Cancer. 2011;63(3):376-80. doi: 10.1080/01635581.2011.535964.
Higher levels of insulin and insulin-like growth factor 1 (IGF-1) increase cancer risk by stimulating cell proliferation and increasing survival of DNA-damaged cells through antiapoptotic mechanisms. Laboratory studies suggest that flaxseed added to the diet may lower circulating levels of insulin and IGF-1, but there is limited information on the effects of dietary flaxseed on these biomarkers of cancer risk in humans. The aim of this study was to determine the effect of flaxseed supplementation in postmenopausal women on serum levels of insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGF-BP3), and C-peptide, a marker of insulin production. Forty-eight postmenopausal women participated in this 12-wk baseline to postintervention study. Participants were asked to consume 7.5 g per day of ground flaxseed for 6 wk and 15 g per day for an additional 6 wk. No significant changes were observed in blood levels of IGF-1, IGF-BP3, or C-peptide over the study intervention. Flaxseed supplementation did not impact circulating levels of IGF-1, IGF-BP3, or C-peptide. Longer duration of intake may be necessary to observe changes in these biomarkers of cancer risk.
胰岛素和胰岛素样生长因子 1（IGF-1）水平升高会通过刺激细胞增殖和通过抗细胞凋亡机制增加 DNA 损伤细胞的存活来增加癌症风险。实验室研究表明，在饮食中添加亚麻籽可能会降低循环中的胰岛素和 IGF-1 水平，但关于饮食中添加亚麻籽对这些人类癌症风险生物标志物的影响的信息有限。本研究旨在确定在绝经后妇女中补充亚麻籽对血清胰岛素样生长因子 1（IGF-1）、胰岛素样生长因子结合蛋白 3（IGF-BP3）和 C 肽（胰岛素产生的标志物）水平的影响。48 名绝经后妇女参加了这项为期 12 周的基线至干预后研究。要求参与者每天食用 7.5 克磨碎的亚麻籽 6 周，然后再额外食用 15 克亚麻籽 6 周。在整个研究干预期间，血液中 IGF-1、IGF-BP3 或 C 肽水平没有明显变化。亚麻籽补充剂不会影响循环中的 IGF-1、IGF-BP3 或 C 肽水平。可能需要更长的摄入时间才能观察到这些癌症风险生物标志物的变化。
