Faculdade de Odontologia, Universidade de São Paulo, Brazil.
Nutr Cancer. 2011;63(3):350-6. doi: 10.1080/01635581.2011.536065.
We examined the association between coffee consumption and oral cancer in a hospital-based case-control study comprising 143 patients with oral and oropharyngeal squamous cell carcinoma attended at 3 major hospitals in Sao Paulo, Brazil, and 240 controls without cancer, recruited from outpatient units of the same hospitals and matched with cases by sex and age. Associations were assessed by multivariate logistic regression conditioned on sociodemographic and behavioral characteristics. Tobacco smoking, alcohol drinking, and higher intake of bacon and deep-fried foods were directly related to disease; the inverse was observed to family income and salad intake. Coffee consumption and tobacco smoking were partially correlated (Spearman correlation coefficient 0.14 among cases, 0.31 among controls). When adjusted for all covariates, a cumulative coffee consumption higher than 18.0 daily liters × year during lifetime was indicated to be protective against disease (adjusted odds ratio 0.39, 95% confidence interval 0.16-0.94, P = 0.037). This observation may have pharmacological implications for clinical medication of these cancers and is relevant to programs aimed at reducing the burden of disease.
我们在巴西圣保罗的 3 家大医院进行了一项基于医院的病例对照研究，调查了咖啡消费与口腔癌之间的关联。该研究纳入了 143 名口腔和口咽鳞状细胞癌患者作为病例组，以及 240 名来自同医院门诊部门且与病例组按性别和年龄相匹配的无癌症对照。通过多变量逻辑回归评估关联，条件为社会人口统计学和行为特征。烟草使用、饮酒以及培根和油炸食品摄入量较高与疾病直接相关；而家庭收入和沙拉摄入量较高则与疾病呈负相关。咖啡消费与烟草使用存在部分相关性（病例组 Spearman 相关系数为 0.14，对照组为 0.31）。在校正所有协变量后，一生中每天饮用超过 18.0 升咖啡与疾病的保护作用相关（调整后的比值比为 0.39，95%置信区间为 0.16-0.94，P=0.037）。这一观察结果可能对这些癌症的临床药物治疗具有药理学意义，并且与旨在降低疾病负担的计划相关。
