Kowalczyk Monika, Turska-Kmieć Anna, Ziółkowska Lidia, Raszek Małgorzata, Kawalec Wanda
Klinika Kardiologii, Instytut Pomnik-Centrum Zdrowia Dziecka, Warszawa.
Med Wieku Rozwoj. 2010 Oct-Dec;14(4):344-9.
Kawasaki disease (KD) is a vasculitis of unknown etiology, the diagnosis is based upon symptoms, characteristic abnormalities in the coronary arteries are the most important complications.
Establishment of a data base of the patients with KD, assignation of symptoms, and frequency of abnormalities in the coronary arteries according to the clinical manifestations and time of the diagnosis.
The patients'data from selected centres of paediatric cardiology were put into a questionnaire form in the Internet. The data of 120 children were placed into data base in the year 2007, of which we analyzed 112 cases.
The most frequent symptoms were fever and abnormalities of oral mucosa. Complete KD was diagnosed in 73%, incomplete in 27% (median of age 28 and 19 months respectively). The disease was diagnosed before its 10th day in 60% with similar frequency of both clinical manifestations, abnormalities in the coronary arteries were observed in 59% with complete and in 44% with incomplete KD clinical sings. The disease lasting longer than 70 days was diagnosed in 40% with similar frequency in both groups of clinical manifestations, abnormalities in the coronary arteries were in 79% with complete and in 75% with incomplete KD. In all cases, abnormalities in coronary arteries were in 67% with complete and in 57% with incomplete KD.
The most frequent symptoms of Kawasaki disease are fever and abnormalities in the oral mucosa. Incomplete KD is more frequent in younger children. Despite complete KD in 40% of cases diagnosis was delayed. Abnormalities in the coronary arteries were more frequent in patients in whom KD was diagnosed only after the 10th day of the illness, but with the same frequency in both clinical manifestations. Diagnosis of incomplete KD before the 10th day of the illness was associated with lower risk of incidence of abnormalities in the coronary arteries.
川崎病（KD）是一种病因不明的血管炎，诊断基于症状，冠状动脉的特征性异常是最重要的并发症。
建立川崎病患者数据库，根据临床表现和诊断时间分配症状及冠状动脉异常的频率。
将选定儿科心脏病中心的患者数据以问卷形式录入互联网。2007年将120名儿童的数据录入数据库，其中分析了112例。
最常见的症状是发热和口腔黏膜异常。73%诊断为完全性KD，27%为不完全性KD（年龄中位数分别为28个月和19个月）。60%在发病第10天前确诊，两种临床表现的频率相似，完全性KD患者中59%观察到冠状动脉异常，不完全性KD临床体征患者中44%观察到冠状动脉异常。40%诊断为病程超过70天的疾病，两组临床表现频率相似，完全性KD患者中79%有冠状动脉异常，不完全性KD患者中75%有冠状动脉异常。所有病例中，完全性KD患者冠状动脉异常率为67%，不完全性KD患者为57%。
川崎病最常见的症状是发热和口腔黏膜异常。不完全性KD在年幼儿童中更常见。尽管40%的病例为完全性KD，但诊断仍有延迟。在发病第10天后才诊断为KD的患者中冠状动脉异常更常见，但两种临床表现的频率相同。在发病第10天前诊断为不完全性KD与冠状动脉异常发生率较低相关。
