Tanaka H, Sakurai Y, Suzuki M, Masunaga S, Mitsumoto T, Fujita K, Kashino G, Kinashi Y, Liu Y, Takada M, Ono K, Maruhashi A
Research Reactor Institute, Kyoto University, Osaka, Japan.
Appl Radiat Isot. 2011 Dec;69(12):1642-5. doi: 10.1016/j.apradiso.2011.03.020. Epub 2011 Mar 21.
A cyclotron-based epithermal neutron source has been developed for boron neutron capture therapy. This system consists of a cyclotron accelerator producing 1.1-mA proton beams with an energy of 30 MeV, a beam transport system coupled with a beryllium neutron production target, and a beam-shaping assembly (BSA) with a neutron collimator. In our previous work, the BSA was optimized to obtain sufficient epithermal neutron fluxes of ~10(9) cm(-2) s(-1) using a Monte Carlo simulation code. In order to validate the simulation results, irradiation tests using multi-foil activation at the surface of a gamma-ray shield located behind the collimator and water phantom experiments using a collimated epithermal neutron beam were performed. It was confirmed experimentally that the intensity of the epithermal neutrons was 1.2×10(9) cm(-2) s(-1).
已开发出一种基于回旋加速器的超热中子源用于硼中子俘获治疗。该系统由一台产生能量为30 MeV、束流为1.1 mA质子束的回旋加速器、一个与铍中子产生靶耦合的束流传输系统以及一个带有中子准直器的束流整形组件(BSA)组成。在我们之前的工作中,使用蒙特卡罗模拟代码对束流整形组件进行了优化,以获得约10⁹ cm⁻² s⁻¹的足够超热中子通量。为了验证模拟结果,在准直器后方的伽马射线屏蔽表面进行了多箔活化辐照测试,并使用准直的超热中子束进行了水体模实验。通过实验证实超热中子强度为1.2×10⁹ cm⁻² s⁻¹。