Centre of Hematology, Oncology and Transfusion Medicine, Vilnius University Hospital Santariskiu Clinics, Santariskiu 2, LT-08661, Vilnius, Lithuania.
Eur J Med Res. 2011 Feb 24;16(2):71-5. doi: 10.1186/2047-783x-16-2-71.
Uveal melanoma (UM) is the most prevalent intraocular malignant tumor in the Western world. The prognosis of survival in the presence of metastatic disease is 2-7 months, depending on the treatment applied. - This article presents a case of metastatic UM with successful complex treatment of liver metastases. - A 49-year old female, underwent removal of the right eyeball in 1996 due to a histologically confirmed uveal melanoma. After 11 years, CT revealed a mass in the left kidney and multiple metastases in the liver. After left nephrectomy, 6 chemotherapy courses with dacarbazine were performed. The increasing liver metastases were observed. Additional 4 intraarterial (i/a) chemotherapy courses were administered using cisplatin, doxorubicin, fluorouracil, and interferon alfa. After few courses increase in CTC Grade 4 liver transaminases was seen. A partial response was observed, and in December 2008 the patient underwent surgery removing all liver metastases by 7 wedge or atypical resections. All margins were tumor-free. 21 months after liver resections and 14 years since dia?gnosis, the patient is alive without evidence of disease. - Successful treatment of metastatic uveal melanoma was due to a timely application of a combination of several treatment methods and good prognostic factors of the patient.
葡萄膜黑色素瘤（UM）是西方世界最常见的眼内恶性肿瘤。转移性疾病存在时的生存预后为 2-7 个月，具体取决于所应用的治疗方法。本文介绍了一例转移性 UM 经成功综合治疗肝转移的病例。一名 49 岁女性，1996 年因组织学证实的葡萄膜黑色素瘤行右眼眼球摘除术。11 年后，CT 显示左肾有肿块和多个肝转移。行左肾切除术，随后进行了 6 个疗程的达卡巴嗪化疗。观察到肝转移逐渐增加。随后又进行了 4 个周期的顺铂、多柔比星、氟尿嘧啶和干扰素α经肝动脉内（i/a）化疗。几个疗程后，CTC 分级的肝转氨酶升至 4 级。观察到部分缓解，2008 年 12 月，患者接受手术切除所有肝转移灶，共进行了 7 个楔形或非典型切除术。所有切缘均无肿瘤。肝切除术后 21 个月，即诊断后 14 年，患者无疾病证据，仍存活。转移性葡萄膜黑色素瘤的成功治疗归因于及时应用多种治疗方法的联合以及患者良好的预后因素。
