Division of Endocrinology, Children's Hospital Boston, Boston, MA 02115, USA.
Horm Res Paediatr. 2011;75(5):322-8. doi: 10.1159/000326684. Epub 2011 Apr 5.
Genome-wide association (GWA) studies are a powerful tool for understanding the genetic underpinnings of human disease. In this article, we briefly review the role and findings of GWA studies in type 1 diabetes, stature, pubertal timing, obesity, and vitamin D deficiency. We then discuss the present and future implications of these findings with regards to disease prediction, uncovering basic biology, and the development of novel therapeutic agents.
全基因组关联 (GWA) 研究是理解人类疾病遗传基础的有力工具。本文简要回顾了 GWA 研究在 1 型糖尿病、身高、青春期发育时间、肥胖和维生素 D 缺乏症中的作用和发现。然后，我们讨论了这些发现对疾病预测、揭示基础生物学和新型治疗药物开发的当前和未来意义。
