Hardjoko F S, Widyanto S, Singgih I, Susilo J
Department of Dermato-Venereology, Gatot Soebroto Central Army Hospital, Jakarta, Indonesia.
Mycoses. 1990 Apr;33(4):167-71. doi: 10.1111/myc.1990.33.4.167.
A clinical trial has been conducted to assess the efficacy of 1% bifonazole and 40% urea ointment for 2 weeks followed by 1% bifonazole cream for one month in the topical treatment of onychomycosis. Thinning and total avulsion of the nails occurred in 97% of 30 patients with candidal onychomycosis and regrowth of a normal appearing nail was found in 92% of 26 patients. Failure rate was 4% and recurrence rate was 12% in 26 patients. Results of the treatment was followed up for 12 weeks. Side effects were negligible.
已开展一项临床试验，以评估1%联苯苄唑和40%尿素软膏治疗2周后再使用1%联苯苄唑乳膏治疗1个月用于甲真菌病局部治疗的疗效。30例念珠菌性甲真菌病患者中有97%出现指甲变薄和完全脱甲，26例患者中有92%长出外观正常的指甲。26例患者的失败率为4%，复发率为12%。对治疗结果进行了12周的随访。副作用可忽略不计。
