Fritsch H, Stettendorf S, Hegemann L
Institute of Anatomy, University of Lübeck, FRG.
Dermatology. 1992;185(1):32-6. doi: 10.1159/000247399.
In the present study, we investigated the effects of bifonazole/urea ointment, a novel topical drug for the treatment of onychomycosis, on the ultrastructure of normal and fungus-infected human toenails by scanning electron microscopy. Nails were treated with the drug ex vivo and compared to untreated controls. During treatment, the corneocyte layers disintegrated, and the structure markedly loosened. After 5 days of treatment, the morphology of fungal cells, found at the undersurface of infected nails, was changed due to the antifungal drug action. The present data demonstrate that by the use of this drug, the agent effectively penetrates the nail plate and affects the fungal cells.
在本研究中，我们通过扫描电子显微镜研究了联苯苄唑/尿素软膏（一种用于治疗甲癣的新型局部用药）对正常和真菌感染的人趾甲超微结构的影响。趾甲在体外接受该药物治疗，并与未治疗的对照进行比较。治疗期间，角质形成细胞层解体，结构明显疏松。治疗5天后，在感染趾甲下表面发现的真菌细胞形态因抗真菌药物作用而改变。目前的数据表明，通过使用这种药物，该制剂可有效穿透甲板并影响真菌细胞。
