针对A4蛋白不同部分产生的抗体可识别唐氏综合征中的一部分斑块。

Antibodies raised against different portions of A4 protein identify a subset of plaques in Down's syndrome.

作者信息

Spargo E, Luthert P J, Anderton B H, Bruce M, Smith D, Lantos P L

机构信息

Department of Neuropathology, Institute of Psychiatry, London, U.K.

出版信息

Neurosci Lett. 1990 Jul 31;115(2-3):345-50. doi: 10.1016/0304-3940(90)90480-w.

DOI:10.1016/0304-3940(90)90480-w

PMID:2146532

Abstract

Antisera were raised to peptides corresponding to residues 1-10 and 12-28 of the published sequence of A4 protein, a 42/43 amino acid long peptide isolated from the brains of patients with Down's syndrome and Alzheimer's disease. Immunohistochemical studies performed on sections of temporal lobe from 12 cases of Down's syndrome showed that the number of senile plaques in the molecular layer of the dentate gyrus which were identified by antibody to A4(1-10) was only 23% (range 11-53%) of that recognised by antibody to A4(12-28). This observation has important consequences for both the diagnosis and the pathogenesis of Down's syndrome and Alzheimer's disease.

摘要

针对与A4蛋白已发表序列中第1至10位和第12至28位残基相对应的肽段制备了抗血清，A4蛋白是一种从唐氏综合征和阿尔茨海默病患者大脑中分离出的42/43个氨基酸长的肽段。对12例唐氏综合征患者颞叶切片进行的免疫组织化学研究表明，由抗A4(1 - 10)抗体识别的齿状回分子层中老年斑的数量仅为抗A4(12 - 28)抗体识别数量的23%（范围为11% - 53%）。这一观察结果对唐氏综合征和阿尔茨海默病的诊断及发病机制都具有重要意义。