手性磷酸对映选择性活化 C(sp3)-氢键：四氢喹啉衍生物的不对称合成。
Selective activation of enantiotopic C(sp3)-hydrogen by means of chiral phosphoric acid: asymmetric synthesis of tetrahydroquinoline derivatives.
机构信息
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
出版信息
J Am Chem Soc. 2011 Apr 27;133(16):6166-9. doi: 10.1021/ja2014955. Epub 2011 Apr 5.
PMID:21466211
Abstract
Chiral phosphoric acid-catalyzed asymmetric C-H functionalization has been achieved. In this process, enantiotopic C(sp(3))-hydrogen is selectively activated by chiral phosphoric acid to afford tetrahydroquinoline derivatives with excellent enantioselectivities (up to 97% ee).
摘要
手性磷酸催化的不对称 C-H 官能化已实现。在这个过程中，手性磷酸选择性地激活对映 C(sp(3))-氢，得到具有优异对映选择性（高达 97%ee）的四氢喹啉衍生物。
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