Westerlind Ulrika, Kunz Horst
Gesellschaft zur Förderung der Analytischen Wissenschaften e.V. ISAS-Leibniz Institute for Analytical Sciences Otto-Hahn-Str. 6b, D-44227 Dortmund, Germany.
Chimia (Aarau). 2011;65(1-2):30-4. doi: 10.2533/chimia.2011.30.
The aberrantly glycosylated and extensively over-expressed membrane-bound mucin MUC1 glycoprotein forms a tumor specific epitope on the surface of epithelial cells. Using defined synthetic glycopeptide structures consisting of the MUC1 tandem repeat region for immunization, antibodies selectively binding to tumor cell surface should be induced. Recent examples of synthetic vaccines directed against the O-glycosylated MUC1 tandem repeats and their immunological evaluation will be given here. These include synthetic MUC1 glycopeptides conjugated to immunostimulants, such as T-cell peptide epitopes, immune carrier proteins or lipid immunostimulants.
异常糖基化且大量过表达的膜结合粘蛋白MUC1糖蛋白在上皮细胞表面形成肿瘤特异性表位。使用由MUC1串联重复区域组成的特定合成糖肽结构进行免疫，应可诱导出选择性结合肿瘤细胞表面的抗体。本文将给出针对O-糖基化MUC1串联重复序列的合成疫苗的近期实例及其免疫学评估。这些包括与免疫刺激剂（如T细胞肽表位、免疫载体蛋白或脂质免疫刺激剂）偶联的合成MUC1糖肽。
