Clinical Pharmacology Department, CHU de Nantes, France.
Am J Clin Dermatol. 2011 Jun 1;12(3):210-3. doi: 10.2165/11318350-000000000-00000.
The term 'baboon syndrome' was introduced in 1984 to describe a special form of systemic, contact-type dermatitis that occurs after ingestion or systemic absorption of a contact allergen in individuals previously sensitized by topical exposure to the same allergen in the same areas. Its clinical picture presents as an erythema of the buttocks and upper inner thighs resembling the red bottom of baboons. This reaction was originally observed with mercury, nickel, and ampicillin. In 2004, some authors proposed the acronym SDRIFE standing for 'symmetric drug-related intertriginous and flexural exanthema' specifically for cases elicited by systemically administered drugs. Since 1984, about 100 cases have been reported in the literature; for most of the concerned drugs, previous skin sensitization or possible cross-sensitization has not been shown. We report the first case of SDRIFE due to rivastigmine, with the exception of an erythematous maculopapular eruption due to rivastigmine that was previously reported. Rivastigmine is a reversible and noncompetitive acetylcholinesterase inhibitor used for the treatment of Alzheimer disease. SDRIFE is an important condition to keep in mind in order to avoid a misdiagnosis when dealing with other exanthematous disorders and to prevent re-exposure to the responsible allergen in the future.
“狒狒综合征”一词于 1984 年被引入，用于描述一种特殊的全身性接触性皮炎，发生于曾因局部接触同一过敏原而致敏的个体摄入或全身吸收接触过敏原后。其临床表现为臀部和大腿内上部的红斑，类似于狒狒的红色臀部。这种反应最初是在用汞、镍和氨苄西林时观察到的。2004 年，一些作者提出了 SDRIFE 的首字母缩写词，代表“对称药物相关的间擦疹和褶皱疹”，专门用于系统给予药物引起的病例。自 1984 年以来，文献中报道了约 100 例；对于大多数相关药物，尚未显示先前的皮肤致敏或可能的交叉致敏。我们报告了首例因rivastigmine 引起的 SDRIFE，除了先前报道的因 rivastigmine 引起的红斑性斑丘疹疹外。rivastigmine 是一种可逆和非竞争性乙酰胆碱酯酶抑制剂，用于治疗阿尔茨海默病。在处理其他出疹性疾病时，为避免误诊，并防止将来再次接触致敏原，应牢记 SDRIFE 这一重要情况。
