Imbernón-Moya Adrian, Podlipnik Sebastian, Burgos Fernando, Vargas-Laguna Elena, Aguilar-Martínez Antonio, Fernández-Cogolludo Eva, Gallego-Valdes Miguel Angel
Department of Dermatology, Hospital Universitario Severo Ochoa, Avenida de Orellana, Leganés, 28911 Madrid, Spain.
Department of Dermatology, Hospital Clinic, Carrer de Villarroel 170, 08036 Barcelona, Spain.
Case Rep Dermatol Med. 2016;2016:7296572. doi: 10.1155/2016/7296572. Epub 2016 Mar 17.
Hypertrichosis is the excessive hair growth in any area of the skin surface. Acquired localized hypertrichosis may be secondary to multiple causes and there is a secondary form due to several drugs, which is usually reversible with discontinuation of the causative agent. Rivastigmine is a reversible and competitive inhibitor of acetylcholinesterase and butyrylcholinesterase used for symptomatic treatment of Alzheimer dementia and Parkinson's disease. It has an adequate safety profile and cutaneous side effects are unusual. Irritant contact dermatitis, allergic dermatitis, baboon syndrome, and cutaneous rash due to rivastigmine have been reported. We report on a Caucasian 80-year-old male with personal history of Alzheimer's disease. The patient started therapy with oral rivastigmine one month prior to clinical presentation of localized hypertrichosis on both forearms. Norgalanthamine has been shown to promote hair growth activity via the proliferation of dermal papilla. Acetylcholinesterase inhibitors can induce hair growth.
多毛症是指皮肤表面任何部位毛发过度生长。获得性局部多毛症可能继发于多种原因，还有一种继发形式是由几种药物引起的，通常在停用致病药物后可逆转。 rivastigmine是一种可逆性竞争性乙酰胆碱酯酶和丁酰胆碱酯酶抑制剂，用于阿尔茨海默病性痴呆和帕金森病的对症治疗。它具有良好的安全性，皮肤副作用不常见。曾有报告称出现过因rivastigmine引起的刺激性接触性皮炎、过敏性皮炎、狒狒综合征和皮疹。我们报告一例80岁白种男性，有阿尔茨海默病个人史。该患者在双前臂出现局部多毛症临床表现前一个月开始口服rivastigmine治疗。去甲加兰他敏已被证明可通过真皮乳头增殖促进毛发生长活性。乙酰胆碱酯酶抑制剂可诱导毛发生长。
