Ritter M M, Richter W O
Medizinische Klinik, Klinikum Grosshadern der Universität München.
Fortschr Med. 1990 Oct 10;108(29):547-9, 554.
Epidemiological studies have identified lipoprotein (a), which has been known since 1963, but has received attention only recently, as a further risk factor for premature arteriosclerosis. This substance is similar to low-density lipoprotein, but it's serum concentration (and thus the increase in risk) is genetically determined and highly variable from one individual to another. The usual dietary and drug measures have only little effect on lipoprotein (a) serum levels. Although the physiological significance of lipoprotein (a) is unknown, it shows great homology to plasminogen, and thus might represent a link between arteriosclerosis and thrombosis.
流行病学研究已将脂蛋白（a）确定为早发性动脉硬化的又一风险因素。脂蛋白（a）自1963年就已为人所知，但直到最近才受到关注。这种物质与低密度脂蛋白相似，但其血清浓度（以及由此产生的风险增加）是由基因决定的，个体之间差异很大。常规的饮食和药物措施对脂蛋白（a）的血清水平影响甚微。尽管脂蛋白（a）的生理意义尚不清楚，但它与纤溶酶原具有高度同源性，因此可能代表动脉硬化与血栓形成之间的一种联系。
