Davidoff P, Bruckert E, Giral P, Doumith R, Thervet F, Truffert J, de Gennes J L
Service d'endocrinologie-métabolisme, l'Hôpital, Paris.
Diabete Metab. 1989 Mar-Apr;15(2):55-60.
Lp(a) is a lipoprotein present in all individuals in concentrations that are genetically determined. Its structure is characterized by the presence of an apoprotein with a high carbohydrate content called apoprotein a. Since 1972, numerous concordant data have endowed Lp(a) with a high risk of atherogenesis. This risk applies to the coronary and cervico-encephalic arteries. For the latter, Lp(a) even is a lipid parameter regarded as a major risk factor. The origin and metabolism of Lp(a) are little known, by they seem to differ from those of low-density lipoproteins. Its specific apoprotein of Lp(a). At the moment, there is no simple dietetic or medicinal treatment that can lower substantially the serum level of Lp(a).
脂蛋白（a）[Lp(a)]是一种存在于所有人体内的脂蛋白，其浓度由基因决定。它的结构特点是存在一种碳水化合物含量高的载脂蛋白，称为载脂蛋白a。自1972年以来，大量一致的数据表明Lp(a)具有较高的动脉粥样硬化风险。这种风险适用于冠状动脉和颈脑动脉。对于后者，Lp(a)甚至是被视为主要危险因素的血脂参数。Lp(a)的起源和代谢鲜为人知，但其似乎与低密度脂蛋白不同。它有特定的载脂蛋白。目前，没有简单的饮食或药物治疗能大幅降低血清Lp(a)水平。
