EFFECTS-262 Research Group, Department of Medical Physiology, School of Medicine, University of Granada, Granada 18012, Spain.
Pediatr Diabetes. 2011 Dec;12(8):704-12. doi: 10.1111/j.1399-5448.2011.00769.x. Epub 2011 Apr 6.
To examine the independent associations of muscular and cardiorespiratory fitness with clustered metabolic risk in adolescents.
Participants were 709 adolescents (346 boys) from 10 European centers, aged 12.5-17.5 yr, evaluated as a part of the Healthy Lifestyle in Europe by Nutrition in Adolescents cross-sectional study (HELENA-CSS). A muscular fitness score was computed using handgrip strength and standing long jump. Cardiorespiratory fitness was measured using the 20-m shuttle run test. Age- and gender-specific z-scores of waist circumference, systolic blood pressure, triglycerides, ratio total cholesterol/high-density lipoprotein cholesterol, and insulin resistance (homeostasis model assessment) were summed to create a metabolic risk score.
Muscular fitness was negatively associated with clustered metabolic risk independent of cardiorespiratory fitness (β = -0.249, p < 0.001). Independent of muscular fitness, an inverse association was also found between cardiorespiratory fitness and clustered metabolic risk (β = 0.264, p < 0.001). The odds ratios for having a high clustered risk (above or equal 1 standard deviation) were 5.3 [95% confidence interval (CI) = 2.6-10.6] and 4.3 (95% CI = 2.0-9.3) in the least fit quartile compared with the most fit quartile for muscular and cardiorespiratory fitness, respectively. Significant differences in metabolic risk between muscular fitness levels persisted among non-overweight (p = 0.012) and overweight participants (p = 0.011).
Muscular and cardiorespiratory fitness are independently associated with metabolic risk in adolescents. These results support current physical activity recommendations for youth, which include muscle strengthening activities in addition to aerobic exercise.
研究青少年肌肉和心肺适能与代谢风险聚集的独立相关性。
参与者为来自 10 个欧洲中心的 709 名青少年（346 名男性），年龄为 12.5-17.5 岁，作为欧洲青少年营养与健康生活方式研究（HELENA-CSS）的一部分进行评估。使用握力和立定跳远计算肌肉适能评分。心肺适能使用 20 米穿梭跑测试进行测量。通过年龄和性别特异性腰围、收缩压、甘油三酯、总胆固醇/高密度脂蛋白胆固醇比值和胰岛素抵抗（稳态模型评估）的 z 分数相加，创建代谢风险评分。
肌肉适能与代谢风险聚集呈负相关，与心肺适能独立相关（β=-0.249，p<0.001）。与肌肉适能独立相关，心肺适能与代谢风险聚集也呈负相关（β=0.264，p<0.001）。在肌肉和心肺适能的最不适合四分位数中，具有高聚集风险（高于或等于 1 个标准差）的可能性比最适合四分位数高 5.3（95%置信区间[CI] = 2.6-10.6）和 4.3（95%CI = 2.0-9.3）。在非超重（p=0.012）和超重参与者（p=0.011）中，肌肉适能水平之间的代谢风险差异仍然显著。
肌肉和心肺适能与青少年的代谢风险独立相关。这些结果支持当前针对青少年的身体活动建议，包括除有氧运动外，还应进行肌肉强化活动。
