具有生物活性信号梯度的兔下颌髁突骨软骨界面再生
Osteochondral interface regeneration of rabbit mandibular condyle with bioactive signal gradients.
作者信息
Dormer Nathan H, Busaidy Kamal, Berkland Cory J, Detamore Michael S
机构信息
Bioengineering Program, University of Kansas, Lawrence, KS 66045, USA.
出版信息
J Oral Maxillofac Surg. 2011 Jun;69(6):e50-7. doi: 10.1016/j.joms.2010.12.049. Epub 2011 Apr 5.
Abstract
PURPOSE
Tissue engineering solutions focused on the temporomandibular joint (TMJ) have expanded in number and variety during the past decade to address the treatment of TMJ disorders. The existing data on approaches for healing small defects in the TMJ condylar cartilage and subchondral bone, however, are sparse. The purpose of the present study was thus to evaluate the performance of a novel gradient-based scaffolding approach to regenerate osteochondral defects in the rabbit mandibular condyle.
MATERIALS AND METHODS
Miniature bioactive plugs for regeneration of small mandibular condylar defects in New Zealand white rabbits were fabricated. The plugs were constructed from poly(D,L-lactic-co-glycolic acid) microspheres with a gradient transition between cartilage-promoting and bone-promoting growth factors.
RESULTS
At 6 weeks of healing, the results suggested that the implants provided support for the neosynthesized tissue as evidenced by the histologic and 9.4 T magnetic resonance imaging findings.
CONCLUSION
The inclusion of bioactive factors in a gradient-based scaffolding design is a promising new treatment strategy for focal defect repair in the TMJ.
摘要
目的
在过去十年中，专注于颞下颌关节（TMJ）的组织工程解决方案在数量和种类上都有所增加，以应对颞下颌关节紊乱的治疗。然而，关于修复颞下颌关节髁突软骨和软骨下骨小缺损方法的现有数据却很稀少。因此，本研究的目的是评估一种新型基于梯度的支架方法在兔下颌髁突再生骨软骨缺损中的性能。
材料与方法
制备用于新西兰白兔下颌髁突小缺损再生的微型生物活性栓。这些栓由聚（D，L-乳酸-共-乙醇酸）微球构建而成，在促进软骨生长因子和促进骨生长因子之间存在梯度过渡。
结果
愈合6周时，结果表明植入物为新合成组织提供了支撑，组织学和9.4 T磁共振成像结果证明了这一点。
结论
在基于梯度的支架设计中加入生物活性因子是一种有前景的颞下颌关节局灶性缺损修复新治疗策略。
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