多巴胺D1受体激动剂SKF 38393对低钙诱导的海马癫痫样放电的抑制作用。
Inhibition of low calcium induced epileptiform discharges in the hippocampus by dopamine D1 receptor agonist, SKF 38393.
作者信息
Smiałowski A
机构信息
Institute of Pharmacology Polish Academy of Sciences, Kraków.
出版信息
Brain Res. 1990 Sep 24;528(1):148-50. doi: 10.1016/0006-8993(90)90208-s.
The influence of dopamine D1 receptor agonist, SKF 38393 has been studied in vitro in the model of low calcium spontaneous epileptiform discharges. Application of SKF 38393 (3 microM) to the perfusing medium evoked a decrease in neuronal firing rate of hippocampal CA1 neurons. The effect of SKF 38393 was blocked by pretreatment with SCH 23390. It is concluded that simulation of hippocampal D1 dopamine receptors by SKF 38393 inhibits epilepsy-like events induced by low calcium concentration in the perfusing fluid.
在低钙自发癫痫样放电模型中，对多巴胺D1受体激动剂SKF 38393的影响进行了体外研究。将SKF 38393（3微摩尔）应用于灌注培养基可引起海马CA1神经元的神经元放电率降低。SKF 38393的作用被SCH 23390预处理所阻断。得出的结论是，SKF 38393模拟海马D1多巴胺受体可抑制灌注液中低钙浓度诱导的癫痫样事件。
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