Palatini P, Mormino P, Martina S, Businaro R, Penzo M, Racioppa A, Guzzardi G, Anaclerio M, Pessina A C
Clinica Medica I, Università degli Studi, Padova.
Cardiologia. 1990 Mar;35(3):217-22.
Purpose of the study was to investigate whether and to what extent blood pressure variability and average night-time blood pressure are related to cardiovascular complications in hypertension. To this aim 60 normotensive and 462 hypertensive subjects were studied by means of non-invasive 24 hour blood pressure monitoring, using either the Avionics, or the ICR Spacelabs, or the Takeda system. Each subject was attributed a target organ damage score on the basis of 12-lead electrocardiogram, chest X-ray and fundoscopy, starting from 0 (no damage) up to 5 (maximum degree of damage). The 522 subjects were subsequently subdivided into 5 classes of increasing average daytime diastolic blood pressure. In each class a higher degree of cardiovascular complications was present in the subjects with the higher blood pressure variability and the higher average night-time blood pressure. From these results it may be inferred that both blood pressure variability and night-time blood pressure are related to the degree of target organ damage in hypertension. This stresses the importance of recording blood pressure throughout the 24 hours.
本研究的目的是调查血压变异性和夜间平均血压是否以及在何种程度上与高血压患者的心血管并发症相关。为此，采用航空电子设备、ICR太空实验室或武田系统，通过无创24小时血压监测对60名血压正常者和462名高血压患者进行了研究。根据12导联心电图、胸部X光片和眼底镜检查，为每个受试者赋予一个靶器官损伤评分，从0（无损伤）到5（最大损伤程度）。随后，将522名受试者分为平均日间舒张压逐渐升高的5组。在每组中，血压变异性较高和夜间平均血压较高的受试者出现心血管并发症的程度更高。从这些结果可以推断，血压变异性和夜间血压均与高血压患者靶器官损伤的程度相关。这强调了24小时全程记录血压的重要性。
