Low Su-Ying, Teo Felicia, Eng Philip, Tan Puay Hoon
Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Outram Road, Singapore.
Asian Cardiovasc Thorac Ann. 2011 Apr;19(2):139-42. doi: 10.1177/0218492311399177.
Pulmonary sclerosing hemangioma is a rare benign tumor for which surgical excision is curative with an excellent prognosis. It often mimics malignancy, making it a diagnostic and management challenge. We reviewed the clinical, radiological, and histopathological characteristics as well as the surgical management of our patients to assess the potential pitfalls in management. All 19 patients who underwent surgical biopsy between January 1999 and December 2009 with a final histopathological diagnosis of pulmonary sclerosing hemangioma were reviewed retrospectively. The median age was 48 years, 89.5% were female, 89.5% were Chinese, and 68.4% were asymptomatic. There were no specific diagnostic radiological characteristics; 1 of 3 patients who underwent combined positron-emission and computed tomography had a false-positive result. Preoperative attempts at establishing a diagnosis were successful in 20% of patients who had invasive procedures. Intraoperative frozen-section evaluation for pulmonary sclerosing hemangioma had an error rate of 25% and a deferred rate of 31%, resulting in nearly half of our patients undergoing unnecessary extensive surgical procedures. We hope to heighten awareness of this diagnosis, thereby increasing the index of suspicion and minimizing errors in diagnosis.
肺硬化性血管瘤是一种罕见的良性肿瘤,手术切除可治愈,预后良好。它常类似恶性肿瘤,给诊断和治疗带来挑战。我们回顾了患者的临床、影像学和组织病理学特征以及手术治疗情况,以评估治疗中的潜在陷阱。回顾性分析了1999年1月至2009年12月期间接受手术活检且最终组织病理学诊断为肺硬化性血管瘤的所有19例患者。中位年龄为48岁,89.5%为女性,89.5%为中国人,68.4%无症状。没有特异性的诊断性影像学特征;3例接受正电子发射断层扫描和计算机断层扫描联合检查的患者中有1例出现假阳性结果。术前尝试进行诊断的侵入性检查在20%的患者中成功。术中对肺硬化性血管瘤进行冰冻切片评估的错误率为25%,延迟率为31%,导致近一半的患者接受了不必要的广泛手术。我们希望提高对该诊断的认识,从而提高怀疑指数并尽量减少诊断错误。