Shimomura Y, Shimizu H, Takahashi M, Uehara Y, Kobayashi I, Kobayashi S
Department of Medicine, Gunma University School of Medicine, Maebashi, Japan.
Exp Clin Endocrinol. 1990 Aug;95(3):385-8. doi: 10.1055/s-0029-1210980.
This study was undertaken to investigate the changes of ambulatory activity and dopamine turnover (DOPAC/DA ratio) in streptozotocin (STZ 60 mg/kg ip)-induced diabetic rats employing the Gunma University-type special apparatus. A significant decrease in ambulatory activity was observed during the dark phase but not during the light phase 1 month after administration of STZ. Moreover, through the precise observation during light phase, we have found out that a significant decrease compared to control periods was observed during 9:00 to 12:00, whereas increase during 12:00 to 15:00 and 5:00 to 18:00 in the diabetic rats. In addition, a significant decrease in dopamine turnover compared to control rats was seen during dark phase (20:00), when significantly decreased ambulation was observed in the diabetic rats compared to control rats. However, no difference in dopamine turnover was observed during light phase (8:00), when ambulation was not significantly different from both groups. These results may suggest that fluctuation in dopamine turnover may be closely related to the ambulatory activity in STZ-induced diabetic rats.
本研究旨在利用群马大学型特殊仪器，调查链脲佐菌素（腹腔注射60mg/kg）诱导的糖尿病大鼠的动态活动和多巴胺周转率（DOPAC/DA比率）的变化。在注射链脲佐菌素1个月后，黑暗期的动态活动显著下降，但光照期未出现这种情况。此外，通过在光照期的精确观察，我们发现糖尿病大鼠在9:00至12:00期间与对照期相比显著下降，而在12:00至15:00和5:00至18:00期间有所增加。另外，与对照大鼠相比，糖尿病大鼠在黑暗期（20:00）的多巴胺周转率显著下降，此时糖尿病大鼠的活动与对照大鼠相比显著减少。然而，在光照期（8:00），两组的活动没有显著差异，此时多巴胺周转率也没有差异。这些结果可能表明，多巴胺周转率的波动可能与链脲佐菌素诱导的糖尿病大鼠的动态活动密切相关。
