Shimomura Y, Shimizu H, Takahashi M, Sato N, Uehara Y, Negishi M, Kobayashi I, Kobayashi S
Department of Medicine, Gunma University of Medicine, Maebashi, Japan.
Physiol Behav. 1990 Jun;47(6):1153-5. doi: 10.1016/0031-9384(90)90366-c.
This study was undertaken to investigate changes in ambulatory and drinking behavior, using the Gunma University-type special apparatus for continuous and direct measurement of ambulation and drinking in streptozotocin-induced diabetic rats (STZ, 60 mg/kg). Ambulatory activity of diabetic rats was significantly less than that of control rats during the dark phase but not during the light phase. Ambulatory activity of diabetic rats was also significantly less from 0900 to 1000 hr, but significantly more from 1400 to 1500 hr and 1700 to 1800 hr than that of control rats. On the other hand, there was significant increase in drinking behavior from DM-1W to DM-4W rats throughout the experimental time. Since diabetic animals are very sick, a wide variety of metabolic systems, including dopamine turnover, would be expected to be altered in these animals, and such alterations could also contribute to the results observed. Further studies are in progress to determine whether these abnormalities will be normalized by insulin administration.
本研究旨在利用群马大学型特殊仪器，对链脲佐菌素诱导的糖尿病大鼠（STZ，60mg/kg）的活动和饮水行为变化进行连续和直接测量。糖尿病大鼠在黑暗期的活动明显少于对照大鼠，但在光照期则不然。糖尿病大鼠在09:00至10:00时的活动也明显较少，但在14:00至15:00时和17:00至18:00时明显多于对照大鼠。另一方面，在整个实验期间，从DM-1W到DM-4W大鼠的饮水行为显著增加。由于糖尿病动物病情严重，预计包括多巴胺代谢在内的各种代谢系统在这些动物中会发生改变，而这种改变也可能导致观察到的结果。目前正在进行进一步的研究，以确定胰岛素给药是否会使这些异常恢复正常。
