Capocaccia R, Farchi G, Mariotti S
Laboratorio di Epidemiologia e Biostatistica, Istituto Superiore di Sanità, Roma.
Epidemiol Prev. 1990 Mar;12(42):34-49.
Liver cirrhosis is considered as a double etiology disease, being its incidence and mortality associated either to alcohol consumption or to a previous viral hepatitis infection of type "B" or "neither A nor B". A two components mathematical model is here used to estimate the proportion of liver cirrhosis mortality attributable to alcohol consumption and the proportion from hepatitis. The model has been fitted to mortality data of the 95 Italian provinces in 5 periods of three years each from 1969 to 1983. In 1981-83, the first-component (interpretable as due to alcohol) is estimated to account for 31% in males and 28% in females of total mortality from liver cirrhosis. Estimates are given also for large geographical areas, regions and provinces.
肝硬化被视为一种双病因疾病,其发病率和死亡率与酒精消费或先前的“B”型病毒肝炎感染或“非甲非乙型”病毒肝炎感染有关。本文使用一个双因素数学模型来估计酒精消费导致的肝硬化死亡率比例以及肝炎导致的比例。该模型已根据1969年至1983年期间每三年为一个阶段的意大利95个省份的死亡率数据进行拟合。在1981 - 1983年期间,第一因素(可解释为由酒精导致)估计占男性肝硬化总死亡率的31%,占女性的28%。还给出了大地理区域、地区和省份的估计值。