Mezger J, Lamerz R, Permanetter W
Department of Internal Medicine III, Klinikum Grosshadern, Munich, Federal Republic of Germany.
J Thorac Cardiovasc Surg. 1990 Dec;100(6):860-6.
The histologic and cytologic distinction of malignant mesothelioma from carcinomas metastatic to the pleura or peritoneum is often problematic. For this reason immunologic methods are being increasingly used as diagnostic adjuncts. This review summarizes 40 studies on the expression of carcinoembryonic antigen in mesotheliomas and in lung and other carcinomas involving the pleura or peritoneum. Carcinoembryonic antigen was identified immunohistochemically in 11% of mesotheliomas and in 84% of carcinomas examined and immunocytochemically (in serous effusions) in 4% and 58%, respectively. In serum and in pleural or ascitic fluid, significantly elevated levels of carcinoembryonic antigen are commonly associated with (lung) carcinomas but rarely with mesotheliomas. Thus, together with identification of the antigen in serum, pleural fluid, or ascitic fluid, immunohistochemical and immunocytochemical techniques for detecting carcinoembryonic antigen provide a valuable aid for distinguishing malignant mesothelioma from metastatic carcinomas.
恶性间皮瘤与转移至胸膜或腹膜的癌在组织学和细胞学上的区分常常存在问题。因此，免疫方法正越来越多地被用作诊断辅助手段。这篇综述总结了40项关于癌胚抗原在间皮瘤以及累及胸膜或腹膜的肺癌和其他癌中的表达的研究。通过免疫组织化学方法，在11%的间皮瘤和84%的所检测癌中鉴定出癌胚抗原；通过免疫细胞化学方法（在浆液性积液中），分别在4%和58%中鉴定出癌胚抗原。在血清以及胸膜或腹水中，癌胚抗原水平显著升高通常与（肺）癌相关，但很少与间皮瘤相关。因此，连同在血清、胸水或腹水中抗原的鉴定，检测癌胚抗原的免疫组织化学和免疫细胞化学技术为鉴别恶性间皮瘤与转移性癌提供了有价值的帮助。
