Munhoz F B A, Godoy-Santos A L, Santos M C L G
Department of Cell Biology, University Federal of Paraná, Curitiba PR, Brazil.
Mol Med Rep. 2010 Sep-Oct;3(5):735-40. doi: 10.3892/mmr.2010.340. Epub 2010 Jul 26.
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that are collectively capable of cleaving virtually all extracellular matrix (ECM) substrates and play an important role in diverse physiological and pathological processes. The activity of MMPs is controlled at multiple levels, and the transcriptional regulation of MMPs appears to represent a necessary step in its regulation. MMP-3 is a key member of the MMP family with broad substrate specificity, and is crucial to the connective tissue remodeling process. It is also involved in the turnover of the numerous ECM components. A common functional promoter polymorphism of MMP-3, 5A/6A, affects its activity and has been associated with various diseases. This polymorphism may be used as a genetic marker for certain pathologies to identify individual susceptibility. This review discusses various topics related to MMP-3 in pathological processes, with a focus on the 5A/6A polymorphism.
基质金属蛋白酶（MMPs）是一类锌依赖性内肽酶，它们共同能够切割几乎所有细胞外基质（ECM）底物，并在多种生理和病理过程中发挥重要作用。MMPs的活性在多个水平受到控制，而MMPs的转录调控似乎是其调控中的一个必要步骤。MMP-3是MMP家族的关键成员，具有广泛的底物特异性，对结缔组织重塑过程至关重要。它还参与众多ECM成分的更新。MMP-3常见的功能性启动子多态性5A/6A会影响其活性，并与多种疾病相关。这种多态性可作为某些病理状态的遗传标记，以识别个体易感性。本综述讨论了与病理过程中MMP-3相关的各种主题，重点是5A/6A多态性。
