Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, University of Melbourne, VIC, Australia.
Cancer Causes Control. 2011 Jun;22(6):885-97. doi: 10.1007/s10552-011-9762-3. Epub 2011 Apr 7.
To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years.
Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders.
Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi.
The association of early-life sun exposure with early-onset melanoma is influenced by host factors.
研究一生中早期暴露于阳光下与 18 至 39 岁之间诊断出的侵袭性皮肤黑色素瘤风险之间的关联。
对来自澳大利亚黑色素瘤家族研究的 606 例病例和 481 例对照进行数据分析，该研究是一项基于人群的病例对照家族研究。通过访谈收集自我报告和父母报告的阳光暴露情况。使用非条件逻辑回归估计比值比（OR），并调整了潜在的混杂因素。
自我报告的儿童期总阳光暴露与黑色素瘤总体无关，但与 18 至 29 岁诊断的黑色素瘤呈正相关（最高与最低四分位的比值比：3.21，95％置信区间（CI）1.38-7.44；P（趋势）0.02；按年龄组的 P（交互作用）0.09）。将分析限制在自我报告的阳光暴露与父母回忆的阳光暴露一致的参与者中，得出的儿童期总阳光暴露最高与最低三分位的比值比为 2.28（95％CI 1.03-5.04；P（趋势）0.05），以及任何与无严重儿童期晒伤的比值比为 2.36（95％CI 1.05-5.31）。自我报告的严重晒伤与黑色素瘤的关联仅在倾向于晒黑而不是晒伤的人群中和痣较少的人群中明显。
一生中早期暴露于阳光下与早发性黑色素瘤的关联受到宿主因素的影响。
