使用晒黑床会增加患恶性黑色素瘤的风险。

Tanning bed exposure increases the risk of malignant melanoma.

作者信息

Ting William, Schultz Kara, Cac Natalie N, Peterson Michael, Walling Hobart W

机构信息

Department of Dermatology, University of Iowa, Iowa City, IA, USA.

出版信息

Int J Dermatol. 2007 Dec;46(12):1253-7. doi: 10.1111/j.1365-4632.2007.03408.x.

DOI:10.1111/j.1365-4632.2007.03408.x

PMID:18173518

Abstract

BACKGROUND

Epidemiologic studies have associated tanning bed exposure and cutaneous melanoma. The relationship between the extent of tanning bed exposure and the risk of melanoma has not been elucidated in detail.

METHODS

Surveys assessing the extent of tanning bed exposure and the history of skin cancer, including malignant melanoma, were collected from academic dermatology clinic patients (n = 1518). Of these, 551 (36.3%) completed all components of the survey. The available medical records, including pathology reports (n = 501; 33%), were reviewed to confirm cases of skin cancer. Data on potential confounding factors, including indoor vs. outdoor occupation and leisure activities, Fitzpatrick skin type, history of blistering sunburn, use of sunscreen and sun protective clothing, history of phototherapy, and level of education, were assessed and compared.

RESULTS

Of the patients surveyed, 487 (32.1%) reported tanning bed exposure. Women aged 45 years or younger accounted for about 60% of all tanning bed users. Seventy-nine cases of malignant melanoma were reported, 22 in women aged 45 years or younger. In the entire cohort, the "ever-use" of tanning beds was found to be a significant risk factor for the development of melanoma [P < 0.05; odds ratio (OR), 1.64; 95% confidence interval (95% CI), 1.01-2.67]. The risk was greater in women aged 45 years or younger (P < 0.05; OR, 3.22; 95% CI, 1.01-11.46). Patients with a history of melanoma were significantly more likely to report tanning bed sessions exceeding 20 min (P < 0.01; OR, 3.18; 95% CI, 1.48-6.82); this association was even stronger for women aged 45 years or younger (OR, 4.12; 95% CI, 1.41-12.02).

LIMITATIONS

The study was subject to recall bias, included only patients at a midwestern academic practice, and had a relatively low response rate.

CONCLUSION

Exposure to tanning beds increases the risk of malignant melanoma, especially in women aged 45 years or younger. These findings reinforce the hazards of tanning bed exposure.

摘要

背景

流行病学研究已将使用晒黑床与皮肤黑色素瘤联系起来。但晒黑床暴露程度与黑色素瘤风险之间的关系尚未得到详细阐明。

方法

从学术性皮肤科门诊患者（n = 1518）中收集评估晒黑床暴露程度和皮肤癌病史（包括恶性黑色素瘤）的调查问卷。其中，551名（36.3%）患者完成了调查问卷的所有部分。查阅现有病历，包括病理报告（n = 501；33%），以确认皮肤癌病例。评估并比较潜在混杂因素的数据，包括室内与室外职业及休闲活动、菲茨帕特里克皮肤类型、水疱性晒伤史、防晒霜和防晒衣物的使用、光疗史以及教育程度。

结果

在接受调查的患者中，487名（32.1%）报告有使用晒黑床的经历。45岁及以下的女性约占所有晒黑床使用者的60%。报告了79例恶性黑色素瘤病例，其中22例发生在45岁及以下的女性中。在整个队列中，发现“曾经使用”晒黑床是黑色素瘤发生的一个显著危险因素[P < 0.05；优势比（OR），1.64；95%置信区间（95%CI），1.01 - 2.67]。45岁及以下女性的风险更高（P < 0.05；OR，3.22；95%CI，1.01 - 11.46）。有黑色素瘤病史的患者报告使用晒黑床时间超过20分钟的可能性显著更高（P < 0.01；OR，3.18；95%CI，1.48 - 6.82）；这种关联在45岁及以下的女性中更强（OR，4.12；95%CI，1.41 - 12.02）。