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血管内治疗鼻出血:适应证、处理和结局。

Endovascular treatment of epistaxis: indications, management, and outcome.

机构信息

Division of Neuroradiology, Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

出版信息

Cardiovasc Intervent Radiol. 2011 Dec;34(6):1190-8. doi: 10.1007/s00270-011-0155-5. Epub 2011 Apr 7.

Abstract

OBJECTIVE

Epistaxis is a common clinical problem, and the majority of bleedings can be managed conservatively. However, due to extensive and sometimes life-threatening bleeding, further treatment, such as superselective embolization, may be required. We report our experience with endovascular treatment of life-threatening epistaxis.

METHODS

All patients presenting with excessive epistaxis, which received endovascular treatment at a German tertiary care facility between January 2001 and December 2009, were retrospectively identified. Demographic data, etiology, origin and clinical relevance of bleeding, interventional approach, therapy-associated complications, and outcome were assessed.

RESULTS

A total of 48 patients required 53 embolizations. Depending on the etiology of bleeding, patients were assigned to three groups: 1) idiopathic epistaxis (31/48), 2) traumatic or iatrogenic epistaxis (12/48), and 3) hereditary hemorrhagic telangiectasia (HHT) (5/48). Eleven of 48 patients required blood transfusions, and 9 of these 11 patients (82%) were termed clinically unstable. The sphenopalatine artery was embolized unilaterally in 10 of 53 (18.9%) and bilaterally in 41 of 53 (77.4%) procedures. During the same procedure, additional vessels were embolized in three patients (3/53; 5.7%). In 2 of 53(3.8%) cases, the internal carotid artery (ICA) was occluded. Long-term success rates of embolization were 29 of 31 (93.5%) for group 1 and 11 of 12 (91.7%) for group 2 patients. Embolization of patients with HHT offered at least a temporary relief in three of five (60%) cases. Two major complications (necrosis of nasal tip and transient hemiparesis) occurred after embolization.

CONCLUSIONS

Endovascular treatment proves to be effective for prolonged and life-threatening epistaxis. It is easily repeatable if the first procedure is not successful and offers a good risk-benefit profile.

摘要

目的

鼻出血是一种常见的临床问题,大多数出血可通过保守治疗进行控制。然而,由于广泛且有时危及生命的出血,可能需要进一步的治疗,如超选择性栓塞。我们报告了在德国一家三级医疗中心对危及生命的鼻出血进行血管内治疗的经验。

方法

回顾性分析了 2001 年 1 月至 2009 年 12 月期间在该德国三级医疗中心因大量鼻出血而接受血管内治疗的所有患者。评估了人口统计学数据、病因、出血部位和临床相关性、介入方法、治疗相关并发症和结果。

结果

共有 48 例患者需要 53 次栓塞治疗。根据出血的病因,患者被分为三组:1)特发性鼻出血(31/48),2)创伤性或医源性鼻出血(12/48),和 3)遗传性出血性毛细血管扩张症(HHT)(5/48)。48 例患者中有 11 例需要输血,其中 9 例(82%)被认为是临床不稳定的。53 次栓塞治疗中有 10 次(18.9%)单侧栓塞了蝶腭动脉,41 次(77.4%)双侧栓塞了蝶腭动脉。在同一过程中,另外 3 名患者(3/53;5.7%)还栓塞了其他血管。在 53 例(3.8%)中,2 例患者内颈动脉(ICA)被闭塞。1 组患者的栓塞长期成功率为 31 例中的 29 例(93.5%),2 组患者的栓塞长期成功率为 12 例中的 11 例(91.7%)。HHT 患者的栓塞治疗至少在 5 例中的 3 例(60%)中提供了暂时缓解。栓塞后发生了 2 例严重并发症(鼻尖坏死和短暂偏瘫)。

结论

血管内治疗对延长且危及生命的鼻出血有效。如果第一次治疗不成功,它很容易重复,并且具有良好的风险效益比。

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