Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Sino-Austrian Center for Biomarker Discovery, Peking University Health Science Center, Beijing, China.
Histol Histopathol. 2011 Jun;26(6):761-8. doi: 10.14670/HH-26.761.
Cyclin A, cyclin E, BUBR1, MAD2 and Aurora A are all cell-cycle regulatory proteins and have been proven to play crucial roles in carcinogenesis. However, their expression patterns in invasive ductal breast carcinoma (IDBC) are controversial and unclear. In this study, we examined the expression status of these candidate proteins in a set of 117 invasive ductal carcinomas, and evaluated their associations with known clinicopathological parameters and the expressions of estrogen receptor, progesterone receptor, Ki-67 and Her-2. Univariate and multivariate data analyses both displayed that positive BUBR1 expression was associated with a high Ki-67 labeling index, and negative MAD2 expression was associated with Her-2 overexpression. Positive BUBR1 expression was also associated with a high histological tumor grade in univariate analysis, but not in multivariate analysis. In addition, high Aurora A expression was weakly associated with lymph node metastasis, and cyclin A was strongly associated with the expression of cyclin E in both univariate and multivariate models. In conclusion, this study suggests that evaluation of BUBR1, MAD2 and Aurora A expression levels is likely to improve accuracy of prognostic predictions in IDBC.
细胞周期蛋白 A、细胞周期蛋白 E、BUBR1、MAD2 和 Aurora A 都是细胞周期调控蛋白，已被证明在肿瘤发生中发挥关键作用。然而，它们在浸润性导管乳腺癌（IDBC）中的表达模式存在争议且尚不明确。在这项研究中，我们检测了 117 例浸润性导管癌中这些候选蛋白的表达状态，并评估了它们与已知临床病理参数以及雌激素受体、孕激素受体、Ki-67 和 Her-2 的表达之间的相关性。单变量和多变量数据分析均显示，BUBR1 阳性表达与 Ki-67 标记指数高有关，MAD2 阴性表达与 Her-2 过表达有关。BUBR1 阳性表达在单变量分析中与组织学肿瘤分级高有关，但在多变量分析中无此相关性。此外，Aurora A 高表达与淋巴结转移弱相关，细胞周期蛋白 A 与细胞周期蛋白 E 的表达在单变量和多变量模型中均呈强相关。总之，本研究表明，评估 BUBR1、MAD2 和 Aurora A 的表达水平可能会提高 IDBC 预后预测的准确性。
