Division of Colon & Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan.
J Surg Oncol. 2011 Sep 1;104(3):265-8. doi: 10.1002/jso.21927. Epub 2011 Apr 6.
The colon is a rare location for gastrointestinal non-Hodgkin's lymphoma. We retrospectively analyzed the demographic data of patients with colonic lymphoma and the possible prognostic factors of the disease.
We studied data obtained from 6,944 patients and performed a retrospective review of patients with primary colonic lymphoma (PCL) by using a pathology registry database. We employed well-established and accepted diagnostic criteria and clinical staging method.
Twenty-nine patients (19 men; 10 women) were diagnosed with PCL. The cecum was the most common tumor location (14/29 patients), and 17 cases (17/29) showed diffuse large-B-cell lymphomas. Four patients died of sepsis within 30 days of an emergency surgery for perforation of intestine. Two-thirds of the patients were in the early disease stages (stages I and II). The overall 5-year survival rate was 47.3%. Disease stage was not a prognostic factor for survival. The overall 5-year survival rate in patients treated with surgery followed by chemotherapy was statistically significant as compared to that in the patients treated with chemotherapy alone.
PCL is a rare malignancy of the gastrointestinal tract, and surgical resection should be considered a part of the standard treatment to achieve a better outcome.
结直肠是胃肠道非霍奇金淋巴瘤的罕见部位。我们回顾性分析了结直肠淋巴瘤患者的人口统计学数据和疾病的可能预后因素。
我们研究了来自 6944 名患者的数据，并通过病理登记数据库对原发性结直肠淋巴瘤（PCL）患者进行了回顾性分析。我们采用了成熟且公认的诊断标准和临床分期方法。
29 名患者（19 名男性；10 名女性）被诊断为 PCL。盲肠是最常见的肿瘤部位（14/29 例），17 例（17/29）表现为弥漫性大 B 细胞淋巴瘤。4 例患者因肠穿孔急诊手术后 30 天内死于脓毒症。三分之二的患者处于疾病早期（I 期和 II 期）。总体 5 年生存率为 47.3%。疾病分期不是生存的预后因素。与单纯化疗相比，接受手术联合化疗治疗的患者的总体 5 年生存率有显著统计学意义。
PCL 是一种罕见的胃肠道恶性肿瘤，手术切除应被视为标准治疗的一部分，以获得更好的结果。
