Davion Simone, Rohan Stephen, Nayar Ritu, Kulesza Peter
Northwestern University, Pathology, Galter 7-132E, 251 E. Huron St., Chicago, IL 60606, USA.
Diagn Cytopathol. 2012 Sep;40(9):826-9. doi: 10.1002/dc.21671. Epub 2011 Apr 6.
The majority of chromophobe renal cell carcinomas (CHRCC) are not aggressive, however, a subset are. The potential for metastasis makes recognition of CHRCC cells in cytologic preparations important for patient surveillance, management, and treatment. We report the detection of an aggressive form of CHRCC in pleural fluid cytology with histopathologic confirmation on subsequent pleural biopsy. Sarcomatoid portions of the original CHRCC, and the pleural metastasis, demonstrated loss of diffuse membranous staining with C-KIT.
大多数嫌色性肾细胞癌（CHRCC）侵袭性不强，然而，有一部分却是侵袭性的。其转移的可能性使得在细胞学标本中识别CHRCC细胞对于患者的监测、管理及治疗很重要。我们报告了在胸腔积液细胞学检查中检测到一种侵袭性CHRCC，并在随后的胸膜活检中得到组织病理学证实。原始CHRCC的肉瘤样部分以及胸膜转移灶显示C-KIT弥漫性膜染色缺失。
