口腔内低水平激光治疗对头颈部癌症放疗患者生活质量的影响。
Effect of intraoral low-level laser therapy on quality of life of patients with head and neck cancer undergoing radiotherapy.
机构信息
Department of Oral Medicine (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil.
出版信息
Head Neck. 2012 Mar;34(3):398-404. doi: 10.1002/hed.21737. Epub 2011 Apr 5.
BACKGROUND
Low-level laser therapy has been used to reduce complications of head and neck cancer treatment. The aim was to assess the impact of laser in the quality of life (QOL) of patients receiving radiotherapy.
METHODS
Sixty outpatients were randomly assigned into 2 groups. The laser group received applications and the placebo group received sham laser. QOL was assessed using the University of Washington QOL questionnaire. A repeated-measures analysis of variance (ANOVA) was used for comparisons of overall QOL scores and Mann-Whitney test compared changes in domain scores.
RESULTS
A decrease in QOL scores was observed in both groups and the reduction in the laser group was significantly lower (p < .01). Changes in QOL scores regarding pain, chewing, and saliva domains were evident in the placebo group. Both health-related QOL and overall QOL were rated higher by patients who received laser therapy.
CONCLUSION
Laser therapy reduces the impact of radiotherapy on the QOL of patients with head and neck cancer.
背景
低水平激光疗法已被用于减少头颈部癌症治疗的并发症。目的是评估激光对接受放射治疗的患者生活质量（QOL）的影响。
方法
将 60 名门诊患者随机分为 2 组。激光组接受应用，安慰剂组接受假激光。使用华盛顿大学 QOL 问卷评估 QOL。采用重复测量方差分析（ANOVA）比较总体 QOL 评分，采用曼-惠特尼检验比较各领域评分的变化。
结果
两组的 QOL 评分均下降，激光组的下降幅度明显较低（p<0.01）。安慰剂组的疼痛、咀嚼和唾液域的 QOL 评分变化明显。接受激光治疗的患者的健康相关 QOL 和总体 QOL 评分均较高。
结论
激光疗法可降低头颈部癌症患者放射治疗对生活质量的影响。
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