Institute of Physiology, Faculty of Medicine, University of Ljubljana, Zaloska cesta 4, Ljubljana, Slovenia.
Department for Surgical Infections, University Medical Center Ljubljana, Zaloska cesta 2, 1000, Ljubljana, Slovenia.
Lasers Med Sci. 2022 Mar;37(2):745-758. doi: 10.1007/s10103-021-03392-0. Epub 2021 Aug 19.
Hyposalivation is a condition represented by a reduced salivary flow and may include symptoms such as mouth dryness (xerostomia), loss of taste, pain, dysphagia, and dysphonia, all of which greatly affect an individual's quality of life.The aim of the present study was to systematically review the effects of low-level light therapy irradiation (photobiomodulation) on salivary gland function in patients with hyposalivation.The main question of the systematic review was: "Does low-level light irradiation therapy of the salivary glands affect salivary flow rate or indicators of salivary function (ion and protein concentrations) in patients with xerostomia or hyposalivation?" The question was based on the PICO (participant, intervention, control, outcome) principle and followed the PRISMA guidelines. Databases were explored and papers published between the years 1997 and 2020 were reviewed for the following Mesh-term keywords and their corresponding entry terms in different combinations: "Low-level light therapy," "Xerostomia," "Saliva," "Salivary glands," "Salivation."The initial sample consisted of 220 articles. Of those, 47 articles were used for full-text analysis and 18 were used for a systematic review, 14 were used in meta-analysis. According to their individual quality, most articles were classified as high quality of evidence according to the GRADE score. Meta-analysis of the evidence observed increase of unstimulated salivary flow 0.51 SMD compared to placebo (95% CI: 0.16-0.86), I = 50%, p = 0.005.The findings of our review revealed evidence of a beneficial effect of photobiomodulation therapy on salivary gland function. The therapy alleviates xerostomia and hyposalivation. However, these effects are reported short term only and did not induce lasting effects of photobiomodulation therapy on patients' quality of life.
唾液分泌减少症是一种唾液流量减少的病症，可能包括口干（口腔干燥症）、味觉丧失、疼痛、吞咽困难和发音困难等症状，所有这些都会极大地影响个体的生活质量。本研究旨在系统回顾低水平光疗照射（光生物调节）对唾液腺功能减退症患者唾液腺功能的影响。系统综述的主要问题是：“低水平光照射唾液腺治疗是否会影响口干或唾液分泌减少症患者的唾液流量率或唾液功能指标（离子和蛋白质浓度）？”该问题基于 PICO（参与者、干预、对照、结果）原则，并遵循 PRISMA 指南。探索了数据库，并对 1997 年至 2020 年期间发表的论文进行了综述，使用了以下 MeSH 术语关键词及其在不同组合中的相应条目术语：“低水平光疗法”、“口腔干燥症”、“唾液”、“唾液腺”、“唾液分泌”。最初的样本包括 220 篇文章。其中，47 篇文章用于全文分析，18 篇文章用于系统综述，14 篇文章用于荟萃分析。根据各自的质量，根据 GRADE 评分，大多数文章被归类为高质量证据。对证据进行荟萃分析观察到与安慰剂相比，未刺激唾液流量增加 0.51 SMD（95%CI：0.16-0.86），I=50%，p=0.005。我们的综述结果表明，光生物调节疗法对唾液腺功能具有有益的效果。该疗法缓解了口干和唾液分泌减少症。然而，这些效果仅在短期报告，并且没有对患者生活质量产生持久的光生物调节治疗效果。
