Sydney Head and Neck Cancer Institute, The Sydney Cancer Centre, Royal Prince Alfred Hospital, Missenden Road, Camperdown, New South Wales, 2050, Sydney, Australia.
Head Neck. 2012 Mar;34(3):365-70. doi: 10.1002/hed.21743. Epub 2011 Apr 5.
The purpose of this study was to determine whether there is a "low-risk" subset of patients with regional metastatic head and neck cutaneous squamous cell carcinoma (SCC) suitable for treatment with surgery alone and omission of adjuvant radiotherapy.
We conducted a retrospective analysis of 168 patients with a single parotid gland or neck nodal metastasis ≤3 cm in size from cutaneous SCC treated with curative intent by surgery ± adjuvant radiotherapy.
Disease-specific survival for the 33 patients treated with surgery alone was 97% at 5 years. In the subset of 19 patients without extracapsular nodal spread (ECS), there was 1 regional recurrence which was successfully salvaged yielding a 5-year disease-specific survival of 100%.
In head and neck cutaneous SCC, the subset with a single node ≤3 cm in size without ECS are at low risk of regional failure and death from cutaneous cancer. These patients may be suitable for single-modality therapy with surgery alone.
本研究旨在确定是否存在局部转移性头颈部皮肤鳞状细胞癌（SCC）的“低危”亚组患者，这些患者适合单独手术治疗并避免辅助放疗。
我们对 168 例因皮肤 SCC 单发腮腺或颈淋巴结转移灶≤3cm 而行根治性手术±辅助放疗的患者进行了回顾性分析。
33 例单纯手术治疗患者的疾病特异性生存率为 5 年 97%。在 19 例无包膜外扩散（ECS）的患者亚组中，仅有 1 例区域复发，经成功挽救后，5 年疾病特异性生存率为 100%。
在头颈部皮肤 SCC 中，单一淋巴结大小≤3cm 且无 ECS 的亚组患者区域复发和皮肤癌死亡的风险较低。这些患者可能适合单独手术作为单一治疗模式。
