Rajewski Marcin, Skrzypczak Jana
Klinika Rozrodczości, Katedra Ginekologii, Połoznictwa i Onkologii Ginekologicznej Uniwersytetu Medycznego w Poznaniu.
Ginekol Pol. 2011 Jan;82(1):32-8.
The aim of the study was to evaluate antiphospholipid antibodies and antiphospholipid syndrome frequency (according to current criteria) in women with recurrent miscarriages.
We examined 105 women diagnosed due to recurrent miscarriages. Patients were divided into 2 groups: with early recurrent miscarriages and with late recurrent miscarriages. The third group was the control group composed of 30 healthy women without poor obstetric history and having at least one child. All women were screened for the presence of antiphospholipid antibodies: anticardiolipin antibodies, anti beta2-glycoprotein antibodies and lupus anticoagulant.
Antiphospholipid antibodies were found in 12.4% of women with recurrent pregnancy loss and in 13.3% of the controls. Among 87 patients in group I with early recurrent miscarriages the most common antibodies were: anti-beta2-glycoprotein I (9.2%), anticardiolipin antibodies (4.6%) and lupus anticoagulant (1.1%). Anti beta2-glycoprotein antibodies were the only antibodies found in 18 women in group II with recurrent late miscarriages. There were 13.3% aPL-positive cases in the control group. Among the studied population, there were only two patients (2.3%) fulfilling the criteria of APS.
本研究旨在评估复发性流产女性中抗磷脂抗体及抗磷脂综合征的发生率（根据现行标准）。
我们检查了105例因复发性流产而确诊的女性。患者被分为两组：早期复发性流产组和晚期复发性流产组。第三组为对照组，由30名无不良产科病史且至少育有一个孩子的健康女性组成。所有女性均接受抗磷脂抗体筛查：抗心磷脂抗体、抗β2糖蛋白抗体和狼疮抗凝物。
复发性流产女性中12.4%发现有抗磷脂抗体，对照组中这一比例为13.3%。在第一组87例早期复发性流产患者中，最常见的抗体为：抗β2糖蛋白I（9.2%）、抗心磷脂抗体（4.6%）和狼疮抗凝物（1.1%）。抗β2糖蛋白抗体是第二组18例晚期复发性流产女性中唯一检测到的抗体。对照组中有13.3%的抗磷脂抗体阳性病例。在研究人群中，仅有两名患者（2.3%）符合抗磷脂综合征的标准。
