Ben Hadj Slama F, Nagara M, Slama A, Braham Jmili N, Monastiri K, Laouani-Kechrid C, Toumi N H, N'Siri B, Samama M, Mahjoub T
Laboratoire d'immunologie, CHU Farhat Hached, 4001 Sousse, Tunisie.
Ann Biol Clin (Paris). 2004 Mar-Apr;62(2):217-21.
Antiphospholipid antibodies are associated with arterial and venous thrombosis and recurrent abortions. However, the prevalence of these antibodies in repeated miscarriages varies in different reports. To obtain quantitative data with restricted criteria and discuss the origin of the variability on the literature, we investigated the presence of antiphospholipid antibodies in 146 women who had 2 or more consecutive pregnancy losses and in 99 women whose pregnancies were successful. Antiphospholipid antibodies (lupus anti-coagulant or anticardiolipin antibodies of 20 or more IgG units) were found in 45% of women with pregnancy losses and in 9% of controls (p < 0.001). The type of loss was determined according to the trimester of pregnancy and the time of the fetal loss. 68% of patients with antiphospholipid antibodies had at least one fetal loss on the second or third trimester compared with 45% of patients without fetal loss (p < 0.01). Further studies should be conducted using more rigorous definition of clinical and laboratory characteristics in a way to allow better comparison between studies.
抗磷脂抗体与动脉和静脉血栓形成以及反复流产有关。然而，这些抗体在反复流产中的患病率在不同报告中有所不同。为了在严格标准下获得定量数据并讨论文献中变异性的来源，我们调查了146名有2次或更多次连续妊娠丢失的妇女以及99名妊娠成功的妇女体内抗磷脂抗体的存在情况。在有妊娠丢失的妇女中，45%发现了抗磷脂抗体（狼疮抗凝物或IgG单位为20或更高的抗心磷脂抗体），而在对照组中这一比例为9%（p<0.001）。流产类型根据妊娠 trimester 和胎儿丢失时间来确定。有抗磷脂抗体的患者中，68%在妊娠中期或晚期至少有一次胎儿丢失，而无胎儿丢失的患者这一比例为45%（p<0.01）。应该采用更严格的临床和实验室特征定义进行进一步研究，以便在不同研究之间进行更好的比较。 （注：原文中“trimester”未准确翻译，可能是“孕期”“ trimester”等意思，这里保留原文未准确翻译的词）
