Deahl S Thomas
Department of Developmental Dentistry, University of Texas Health Science Center at San Antonio Dental School, San Antonio, Texas 78258, USA.
Tex Dent J. 2011 Feb;128(2):211-9.
The Number Needed to Treat (NNT) is a tool useful for comparing the relative effectiveness of two or more therapeutic or preventive interventions. The NNT may be presented by authors of a clinical research article, or, if not provided, may be calculated by the reader if the authors have reported outcomes as positive or negative per research subject. The NNT is simply calculated as the inverse of the absolute risk reduction. The NNT is most meaningful when reported within a confidence interval and when describing clinical trials of higher validity such as randomized controlled trials and meta-analyses of such trials. Several example NNTs from the dental and medical literature are reported.
需治疗人数(NNT)是一种有助于比较两种或更多治疗性或预防性干预措施相对有效性的工具。临床研究文章的作者可能会给出需治疗人数,或者,如果未给出,读者可在作者已按每个研究对象报告了阳性或阴性结果的情况下进行计算。需治疗人数简单计算为绝对风险降低率的倒数。当在置信区间内报告以及在描述诸如随机对照试验和此类试验的荟萃分析等较高效度的临床试验时,需治疗人数最具意义。文中报告了来自牙科和医学文献的几个需治疗人数示例。