Kulenkampff H A, Delling G
Abteilung Osteopathologie, Universität Hamburg.
Z Orthop Ihre Grenzgeb. 1990 Sep-Oct;128(5):447-52. doi: 10.1055/s-2008-1039594.
In almost 80% of all skeletal metastases of carcinoma of the prostate, osteoneogenesis by "normal" osteoblasts can be detected in the surrounding tissue. The object of the present study was to perform a quantitative histomorphometric analysis of this local osteoblast stimulation. In tissue with metastases, the relative proportion of osteoid and mineralized bone tissue per unit of volume (Vv = 46%) was three times higher than the norm (Vv = 15%). Although the lamellar spongiosa (Pm = 19%) was only slightly higher than the physiological values (Pm = 15%), a considerable increase in fibrous bone tissue (PFK = 39%) was found (normal value: 1-2%). The volumetric density of the osteoid (POST = 7%) had also increased (normal value: 7%). While the mean width of the trabecula of the lamellar spongiosa was within normal range (dTRAB/LK = 136 microns), appositional accumulation of a 62 microns thick fibrous bone layer resulted in a distinct tumefaction of the trabeculae. The width of the osteoid border (dapp.OST) was 22 microns (normal value: 13 microns). The majority of the activated osteoblasts were 30-150 microns from the neighboring tumor cells.
在前列腺癌的所有骨骼转移中，近80%可在周围组织中检测到“正常”成骨细胞的骨生成。本研究的目的是对这种局部成骨细胞刺激进行定量组织形态计量分析。在有转移的组织中，每单位体积类骨质和矿化骨组织的相对比例（Vv = 46%）比正常情况（Vv = 15%）高出三倍。尽管板层骨小梁（Pm = 19%）仅略高于生理值（Pm = 15%），但发现纤维性骨组织有相当大的增加（PFK = 39%）（正常值：1 - 2%）。类骨质的体积密度（POST = 7%）也有所增加（正常值：7%）。虽然板层骨小梁的平均宽度在正常范围内（dTRAB/LK = 136微米），但62微米厚的纤维性骨层的贴壁堆积导致骨小梁明显肿胀。类骨质边界的宽度（dapp.OST）为22微米（正常值：13微米）。大多数活化的成骨细胞距离相邻肿瘤细胞30 - 150微米。
