Clarke N W, McClure J, George N J
Department of Urological Surgery, University Hospital South Manchester, UK.
Eur Urol. 1993;24(2):286-90. doi: 10.1159/000474311.
This study has examined the effect of prostate cancer on bone matrix formation and mineralisation by osteoblasts, with special reference to osteomalacia. Sixty-seven patients with prostatic bone metastases underwent transiliac bone biopsy after double tetracycline labelling. Histomorphometric analysis was then undertaken in areas distant from, local to and infiltrated by prostate cancer. In bone free of tumour (n = 45) and bone surrounding metastases (n = 7) both matrix formation and corrected mineral apposition rate were low. By comparison osteoid surface, osteoid volume and mineral apposition rate were markedly increased within metastases (tumor-free bone vs. metastatic bone, p < 0.0001), a finding consistent with a high bone turnover state. Although osteoblast function was disturbed both within metastases and in tumour-free areas, classical osteomalacia was not associated with prostate cancer.
本研究检测了前列腺癌对成骨细胞骨基质形成和矿化的影响，并特别提及骨软化症。67例有前列腺骨转移的患者在双四环素标记后接受了髂骨活检。然后在远离前列腺癌、前列腺癌局部及受其浸润的区域进行组织形态计量分析。在无肿瘤的骨组织（n = 45）和转移灶周围的骨组织（n = 7）中，基质形成和校正后的矿物质沉积率均较低。相比之下，转移灶内类骨质表面、类骨质体积和矿物质沉积率显著增加（无肿瘤骨组织与转移骨组织相比，p < 0.0001），这一发现与高骨转换状态一致。尽管转移灶内和无肿瘤区域的成骨细胞功能均受到干扰，但典型的骨软化症与前列腺癌无关。
