干扰素在病毒感染及抗体形成中的作用。
The role of interferon in virus infections and antibody formation.
作者信息
Stanton G J, Johnson H M, Baron S
出版信息
Pathobiol Annu. 1978;8:285-313.
PMID:214736
Abstract
Virus-type interferon is capable of suppressing the antibody response both in vivo and in vitro. Interferon induced by antigen or mitogen (immune interferon), primarily in T-lymphocytes, also appears capable of suppressing the antibody response. Cyclic AMP has a regulatory effect on the induction of both virus-type and immune interferon. The immunosuppressive effects of virus-type and immune interferon may differ at the cellular or subcellular level.
摘要
病毒型干扰素在体内和体外均能抑制抗体反应。由抗原或有丝分裂原诱导产生的干扰素（免疫干扰素），主要在T淋巴细胞中产生，似乎也能够抑制抗体反应。环磷酸腺苷（cAMP）对病毒型干扰素和免疫干扰素的诱导均有调节作用。病毒型干扰素和免疫干扰素的免疫抑制作用在细胞或亚细胞水平上可能有所不同。
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