Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Antioxid Redox Signal. 2011 Aug 1;15(3):845-51. doi: 10.1089/ars.2011.3977. Epub 2011 Jun 6.
Dr. Arne Holmgren (Ph.D., 1968) is recognized here as a redox pioneer, because he has published at least one article on redox biology that has been cited over 1000 times and has published at least 10 articles, each cited over 100 times. He is widely known for his seminal discoveries and in-depth studies of thioredoxins, thioredoxin reductases, and glutaredoxins. Dr. Holmgren, active throughout his career at Karolinska Institutet, Sweden, has led the field of research about these classes of proteins for more than 45 years, continuously building upon his sequence determination of Escherichia coli thioredoxin in the late 1960s and discovery of the thioredoxin fold in the 1970s. He discovered and named glutaredoxin and he determined the structure and function of several members of these glutathione-dependent disulfide oxidoreductases. He still continues to broaden the frontiers of knowledge of thioredoxin and glutaredoxin systems. The thioredoxin fold is today recognized as one of the most common protein folds and the intriguing complexity of redox systems, redox signaling, and redox control of cellular function is constantly increasing. The legacy of Dr. Holmgren's research is therefore highly relevant and important also in the context of present science. In a tribute to his work, questions need to be addressed toward the physiological importance of redox signaling and the impact of glutaredoxin and thioredoxin systems on health and disease. Dr. Holmgren helped lay the foundation for the redox biology field and opened new vistas in the process. He is truly a redox pioneer.
阿恩·霍尔姆格伦博士（博士，1968 年）在此被视为氧化还原领域的先驱，因为他发表了至少一篇氧化还原生物学方面的论文，该论文被引用超过 1000 次，并且发表了至少 10 篇每篇被引用超过 100 次的论文。他因对硫氧还蛋白、硫氧还蛋白还原酶和谷氧还蛋白的开创性发现和深入研究而广为人知。霍尔姆格伦博士在瑞典卡罗林斯卡学院的整个职业生涯中都非常活跃，他领导了这些蛋白质类别的研究领域超过 45 年，不断建立在他在 20 世纪 60 年代后期对大肠杆菌硫氧还蛋白的序列测定和 70 年代发现硫氧还蛋白折叠的基础上。他发现并命名了谷氧还蛋白，并确定了这些谷胱甘肽依赖的二硫氧化还原酶的几个成员的结构和功能。他仍然在继续拓宽硫氧还蛋白和谷氧还蛋白系统的知识前沿。硫氧还蛋白折叠结构如今被认为是最常见的蛋白质折叠结构之一，氧化还原系统、氧化还原信号以及氧化还原对细胞功能的控制的复杂程度也在不断增加。因此，霍尔姆格伦博士的研究成果在当今科学背景下仍然具有高度的相关性和重要性。为了向他的工作致敬，需要解决氧化还原信号的生理重要性以及谷氧还蛋白和硫氧还蛋白系统对健康和疾病的影响等问题。霍尔姆格伦博士帮助为氧化还原生物学领域奠定了基础，并在此过程中开辟了新的视野。他确实是氧化还原领域的先驱。
