Roszkowski K, Beuth J, Ko H L, Peters G, Pulverer G
Institut für Med. Mikrobiologie und Hygiene, Universität zu Köln.
Zentralbl Bakteriol. 1990 Sep;273(4):518-30. doi: 10.1016/s0934-8840(11)80459-7.
The in vitro activity of erythromycin and clarithromycin (a new macrolide antibiotic) on clinical bacterial isolates as well as their effects on the cellular and humoral immune responses in BALB/c-mice and on human granulocytes/monocytes was investigated. Treatment of BALB/c-mice for 7 days with these drugs did not influence the delayed type hypersensitivity to oxazolone nor the production of IgG and IgM immunoglobulins. In vitro, exposure of granulocytes to erythromycin resulted in increased phagocytosis only in higher concentrations (20 mcg/ml), whereas clarithromycin enhanced chemiluminescence response of granulocytes in concentrations ranging from 2.5-20 mcg/ml. Subinhibitory concentrations of both substances modified Staphylococcus aureus and made them more susceptible for granulocyte phagocytosis.
研究了红霉素和克拉霉素（一种新型大环内酯类抗生素）对临床分离细菌的体外活性，以及它们对BALB/c小鼠细胞免疫和体液免疫反应及对人粒细胞/单核细胞的影响。用这些药物对BALB/c小鼠治疗7天，并不影响对恶唑酮的迟发型超敏反应，也不影响IgG和IgM免疫球蛋白的产生。在体外，仅在较高浓度（20 mcg/ml）下，粒细胞暴露于红霉素会导致吞噬作用增强，而克拉霉素在2.5 - 20 mcg/ml浓度范围内可增强粒细胞的化学发光反应。两种物质的亚抑菌浓度可改变金黄色葡萄球菌，使其更易被粒细胞吞噬。
