给母鼠施用氯氮平会增强幼鼠对分离和再分离的超声发声反应：与氟哌啶醇的对比。
Administration of clozapine to a mother rat potentiates pup ultrasonic vocalization in response to separation and re-separation: contrast with haloperidol.
机构信息
Department of Psychology, University of Nebraska-Lincoln, Lincoln, USA.
出版信息
Behav Brain Res. 2011 Sep 23;222(2):385-9. doi: 10.1016/j.bbr.2011.03.062. Epub 2011 Apr 5.
Abstract
The present study examined how haloperidol (typical) and clozapine (atypical) treatment to mother rats affected their pups' ultrasonic vocalization (USV) response to maternal separation and re-separation (termed "maternal potentiation"). Clozapine (10 mg/kg, sc) but not haloperidol (0.2 mg/kg, sc) significantly enhanced the maternal potentiation of 40 kHz USVs in pups that were briefly reunited with their dams. This novel paradigm provides an indirect way of assessing the impact of antipsychotic treatment on the quality of maternal care. It may also be useful in examining the impact of antipsychotic treatment on social bonding between infants and mothers.
摘要
本研究考察了母亲大鼠接受氟哌啶醇（典型）和氯氮平（非典型）治疗如何影响其幼崽对母体分离和再分离（称为“母体增强”）的超声波发声（USV）反应。氯氮平（10mg/kg，sc）而非氟哌啶醇（0.2mg/kg，sc）显著增强了与母体短暂团聚的幼崽中 40kHz USV 的母体增强作用。这种新的范式提供了一种间接评估抗精神病药物治疗对母婴护理质量影响的方法。它也可能有助于研究抗精神病药物治疗对婴儿和母亲之间社会联系的影响。
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