Gannon Matthew A, Brown Clifford J, Stevens Rachel M, Griffith Molly S, Marczinski Cecile A, Bardgett Mark E
Department of Psychological Science, Northern Kentucky University, United States.
Department of Psychological Science, Northern Kentucky University, United States.
Pharmacol Biochem Behav. 2015 Mar;130:90-6. doi: 10.1016/j.pbb.2015.01.007. Epub 2015 Jan 17.
Risperidone is an antipsychotic drug that is approved for use in childhood psychiatric disorders such as autism. One concern regarding the use of this drug in pediatric populations is that it may interfere with social interactions that serve to nurture brain development. This study used rats to assess the impact of risperidone administration on maternal-offspring interactions and juvenile play fighting between cage mates. Mixed-sex litters received daily subcutaneous injections of vehicle or 1.0 or 3.0mg/kg of risperidone between postnatal days (PNDs) 14-42. Rats were weaned and housed three per cage on PND 21. In observations made between PNDs 14-17, risperidone significantly suppressed several aspects of maternal-offspring interactions at 1-hour post-injection. At 23 h post-injection, pups administered risperidone had lower activity scores and made fewer non-nursing contacts with their moms. In observations of play-fighting behavior made once a week between PNDs 22-42, risperidone profoundly decreased many forms of social interaction at 1h post-injection. At 23h post-injection, rats administered risperidone made more non-social contacts with their cage mates, but engaged in less social grooming. Risperidone administration to rats at ages analogous to early childhood through adolescence in humans produces a pattern of abnormal social interactions across the day that could impact how such interactions influence brain development.
利培酮是一种已被批准用于治疗儿童精神疾病（如自闭症）的抗精神病药物。在儿科人群中使用这种药物的一个担忧是，它可能会干扰有助于促进大脑发育的社交互动。本研究使用大鼠来评估给予利培酮对母鼠与幼崽间互动以及同笼伙伴间幼年期打斗行为的影响。在出生后第14至42天，将不同性别的幼崽每日皮下注射赋形剂或1.0或3.0mg/kg的利培酮。大鼠在出生后第21天断奶，每笼饲养三只。在出生后第14至17天进行的观察中，利培酮在注射后1小时显著抑制了母鼠与幼崽间互动的几个方面。在注射后23小时，接受利培酮的幼崽活动得分较低，与母亲的非哺乳接触较少。在出生后第22至42天每周进行一次的打斗行为观察中，利培酮在注射后1小时显著减少了多种形式的社交互动。在注射后23小时，接受利培酮的大鼠与同笼伙伴进行更多的非社交接触，但社交梳理行为较少。在与人类幼儿期至青春期相当的年龄段给大鼠施用利培酮，会导致全天出现异常社交互动模式，这可能会影响此类互动对大脑发育的影响。
