Godfrey K M, James M P
Department of Dermatology, Royal Berkshire Hospital, Reading, U.K.
Br J Dermatol. 1990 Nov;123(5):653-5. doi: 10.1111/j.1365-2133.1990.tb01483.x.
Four patients with inflammatory bowel disease and severe cystic acne were treated with isotretinoin. Two patients had a successful course of treatment without any gastrointestinal side-effects. One patient had two episodes of profuse rectal bleeding that were probably related to pre-existing haemorrhoids. The fourth patient had a flare-up of his Crohn's disease after starting isotretinoin.
4例炎症性肠病合并重度囊肿性痤疮患者接受了异维A酸治疗。2例患者治疗过程顺利，未出现任何胃肠道副作用。1例患者发生两次大量直肠出血，可能与既往存在的痔疮有关。第4例患者在开始使用异维A酸后克罗恩病病情加重。
