Park Won Soon, Ahn So Yoon, Sung Se In, Ahn Jee-Yin, Chang Yun Sil
Cell Transplant. 2017 Mar 13;26(3):439-448. doi: 10.3727/096368916X694193. Epub 2016 Nov 30.
Severe intraventricular hemorrhage (IVH) remains a major cause of mortality and long-term neurologic morbidities in premature infants, despite recent advances in neonatal intensive care medicine. Several preclinical studies have demonstrated the beneficial effects of mesenchymal stem cell (MSC) transplantation in attenuating brain injuries resulting from severe IVH. Because there currently exists no effective intervention for severe IVH, the therapeutic potential of MSC transplantation in this intractable and devastating disease is creating excitement in this field. This review summarizes recent progress in stem cell research for treating neonatal brain injury due to severe IVH, with a particular focus on preclinical data concerning important issues, such as mechanism of protective action and determining optimal source, route, timing, and dose of MSC transplantation, and on the translation of these preclinical study results to a clinical trial.
尽管新生儿重症监护医学最近取得了进展，但严重脑室内出血（IVH）仍然是早产儿死亡和长期神经功能障碍的主要原因。多项临床前研究已证明间充质干细胞（MSC）移植在减轻严重IVH所致脑损伤方面的有益作用。由于目前尚无针对严重IVH的有效干预措施，MSC移植在这种棘手且具有破坏性的疾病中的治疗潜力正在该领域引发关注。本综述总结了干细胞研究在治疗严重IVH所致新生儿脑损伤方面的最新进展，特别关注有关重要问题的临床前数据，如保护作用机制以及确定MSC移植的最佳来源、途径、时机和剂量，以及这些临床前研究结果向临床试验的转化。
